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Wellcome will fund researchers and teams who will validate markers to enable stratification in anxiety and/or depression as early as possible.

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This call aims to support validation of biological, psychological, social or digital markers to enable stratification in anxiety and/or depression as early as possible. Stratification will allow targeted treatment and ensure that the right people get the right treatment at the right time. 

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Disabled applicants

If you are disabled or have a long-term health condition, we can support you with the application process.

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About this call
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About this call
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As part of our new strategic focus, Wellcome aims to drive a transformative change in the ability to intervene as early as possible in the course of anxiety and depression, broadly defined, in ways prioritised by the people who experience them. This work involves advancing scientific understanding of how brain, body and environment interact in the course and resolution of these conditions; finding new and improved ways to predict, identify, and stratify groups of people so that we can provide more timely and personalised interventions; and finding new and improved ways of intervening.

We recognise that to make progress we need to bring together an equitable, ethical, diverse and global research community to focus on the value of stratification for mental health. Through this call, we aim to foster the field of stratification in mental health research by encouraging applications from multi-disciplinary teams from diverse settings, both geographical and in terms of level of resource. We are also looking to encourage equitable collaborations between low- and middle-income countries (LMICs) and high-income countries (HICs) so that findings may be applicable globally.

Current mental health diagnostic categories are imperfect, and rely on subjective measures, resulting in significant heterogeneity of people within each diagnostic category, which in turn impacts development and provision of effective interventions. Stratified medicine aims to identify sub-groups of individuals within a heterogenous disease population based upon unique characteristics of each sub-group (strata) such as underlying mechanisms, risk factors, course of disease or treatment responses.

A number of different methods can be utilised to measure the unique characteristics of the sub-groups including, but not limited to:

  • genetics
  • biochemical
  • imaging
  • clinical scores
  • socio-demographic characteristics
  • behavioural or psychological assessments

Use of stratification approaches have the potential to identify the sub-groups of individuals that will benefit most from a targeted pharmacological or non-pharmacological treatment. Furthermore, stratification of people with mental health conditions will enable early intervention with the potential to alter trajectories of these conditions and have maximum impact on people’s lives.

In this call, we aim to advance stratification in anxiety and/or depression, through funding further validation of promising biological, psychological, social and digital markers, whether alone or in combination with observable or behavioural characteristics, with a goal to enable early identification of sub-groups and targeted treatment.

Throughout the duration of the funding, Wellcome will encourage collaboration between funded groups through engagement activities (for example webinars and workshops), to support external validation efforts, in order to foster the field of stratification in mental health research and support the building of a community of stakeholders from various settings.

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Eligibility and suitability
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Eligibility and suitability
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What are we looking for?

We are seeking applications that focus on the validation of markers that can be used for stratification in anxiety and/or depression.

Markers may be biological, psychological, social or digital and may be used in combination with observable or behavioural characteristics to enable stratification according to risk/susceptibility, diagnosis, prognosis, prediction, underlying mechanisms or monitoring of anxiety and/or depression.

Markers should have the potential to be applied on a large scale or have broad acceptability in different settings and must seek to enable early identification and/or early intervention.

  • We take anxiety and depression as broadly defined categories to include all types of anxiety and depressive disorder (including obsessive compulsive disorder, post-traumatic stress disorder and bipolar disorder).
  • We recognise that the current diagnostic categories are imperfect but removing all categories or creating new ones also presents difficulties. We, therefore, use the terms anxiety and depression to refer to overlapping constellations of thoughts, feelings and behaviours that have historically been classified as discrete conditions.
  • In this call, we are focusing on markers relevant to anxiety and/or depression only.

Applications should focus on marker(s) with a clear underlying hypothesis and there should be robust pilot data to support the marker selection. We will accept applications at any stage along the development pipeline, but the proposal must enable progression to the next stage of development.

Applications must also consider ethical implications in both design and uptake, reflect on risks and potential mitigation strategies/considerations, and involve people with lived experience in their proposed research project.

We want to support validation of markers in diverse settings, including external validation of markers in low resource settings, if not developed there initially, and encourage multi-disciplinary collaboration between researchers, including between low- and middle-income countries and high-income countries (where applicable).

External guidance is provided through the MRC Stratification Framework and UKCDR guidance on equitable partnerships.

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As a member of the Common Measures Board for Mental Health Science, Wellcome is committed to identifying and adopting common measures so that, in time, data can be combined and compared across studies to answer crucial research questions.

Please see our guidance on common metrics for mental health research for more information on which metrics you should use.

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We are committed to the meaningful involvement of lived experience experts in the direction and decision making of the mental health team, the projects and research that we fund, and in the field of mental health science.

In this call specifically, it is crucial to involve lived experience experts in your research projects to ensure the applicability and acceptability of the research and findings to end users. Historically, people with lived experience have been excluded from contributing to the design, governance and delivery of research and therefore it is important that mental health research henceforth takes their opinions into account.

Applications must demonstrate the involvement of lived experience expertise in the planning, design, and delivery of the research, including how you plan to build capacity of lived experience experts in the field of stratification in mental health research more broadly.

We recognise that there are a range of ways that research teams can involve and collaborate with people with lived experience. For example, this may include, but not be limited to:

  • expert advisors
  • co-applicants
  • collaborators
  • advisory group members

We are open to any methods of involvement that teams choose but expect lived experience experts to be involved in the most appropriate ways to inform multiple aspects and stages of the research project. Key for us is that this is not tokenistic or a tick box exercise.

For further information on what we mean by ‘people with lived experience’, including guidance for meaningful involvement, please see the guidance document.

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We expect the following to be considered, as is relevant to the proposal:

  • the subsequent development/validation steps required to ensure consideration of entire development pathway
  • any clinical, manufacturing, regulatory or marketing issues known that may affect implementation and if so how these will be addressed
  • downstream development or implementation partner(s)
  • the target product profile or key desired attributes of your marker for stratification
  • the potential future implementation strategy on how these markers could be used in practice, such as point in the care pathway (for example point of care blood test, laboratory-based testing or clinical observation), method and frequency of measurement of marker in practice
  • how markers may add value to the healthcare system such as by avoiding unnecessary treatments, improving treatment efficiency or avoiding more costly interventions later
  • consideration of mechanisms to advance equitable access to the assets developed through this research
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Research must consider potential uptake from the outset. For example:

  • Applicants should engage with potential end users of research, including people with lived experience of anxiety and depression, caregivers/families, clinicians and service managers for future implementation and impact for policy.
  • Applicants may engage with stakeholders, such as policymakers, health care professionals, regulatory bodies and downstream partners, as appropriate, during the research process to ensure results are implementable, scalable, suitable for commercialisation and in line with policy and end users’ needs.
  • Applicants may employ a mixed methods approach and include social science and health economics expertise (as appropriate) to ensure that the stratification markers are appropriate, acceptable and feasible and that any potential social, cultural or economic barriers to implementation are examined.
  • Proposed research may consider and include measures such as (but not limited to) acceptability, adoption, appropriateness, affordability, costs, feasibility, fidelity, penetrance and sustainability, as relevant.
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What are we not looking for?

The following are out of scope for this Mental Health Award:

  • studies exploring neurodevelopmental conditions, neurodegenerative diseases, or mental health problems outside of anxiety and/or depression (for example psychosis, eating disorders and substance abuse)
  • replication of existing studies unless limitations are clearly identified in the proposal or marker is being validated in a different context or setting
  • research to support chronic management unless relevant to advance early intervention
  • ‘blue skies’ or purely curiosity-driven research
  • epidemiological studies
  • applications with research involving healthy volunteers as the sole focus of the proposal
  • phase III trials of pharmacological interventions, although please contact us to discuss repurposing opportunities
  • implementation science research as the sole focus of the proposal
  • health systems research around the distribution and uptake of interventions
  • direct service provision or support for access to current services.
  • healthcare reorganisation
  • applications that do not include the involvement of lived experience experts in the proposed project
  • applications that do not comply with Wellcome’s research environment principles of open science and relevant diverse inputs
  • applications that fail to articulate or evidence review of ethical considerations relating to the research and potential uptake, as well as review of the risks and mitigation strategies/considerations to address them
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Under ‘Details of proposal’ section

In this section, you should set out how the proposed research fits the specification for this funding call.

This should include your scientific goals, details of the research and your plans to involve people with lived experience in your research. All points listed below must be addressed for your application to be considered eligible.

We provide guidance on the approximate word count per section. Provide all relevant information within the application form; do not refer to additional unpublished information on personal websites.

Please use the following headings within the ‘Details of proposal’ section:

i. The unmet need and supporting evidence (250 words)

Please include:

Justification for your choice of marker, proposed study sample (strata) and location, including an overview of the evidence supporting the value of the marker for stratification in anxiety and/or depression, how it can be used to stratify and the underlying hypothesis of its use.

ii. Project plan (500 words)

Define the primary objective of the proposal and briefly summarise the proposed work plan and how this will advance development of the proposed marker to the next stage. You should clearly state:

  1. the specific aims and objectives of the proposed project
  2. the proposed methodology under each work package

If relevant, and as applicable, include details on the interventions, target population, study design, sample size and data analysis plans.

iii. Lived experience involvement (250 words maximum)

Describe how people with lived experience will be meaningfully involved throughout the project (for example, during project design, data collection, analysis and dissemination). If people with lived experience are excluded at any stage of the project, please briefly justify why.

You may provide your answer in text entry format or as a PDF attachment. If you are uploading your answer:

  • The uploaded document must be in 11-point Arial font and portrait format.
  • References are not required in this section, but you may provide them.
  • Citations embedded in the text will count towards your word limit (note that a list of references at the end will not count towards the word limit, but please keep this as brief as possible).
  • Only include figures and tables that are directly relevant to your proposed research (for example, one figure of preliminary data or a Gantt chart of project plan). These will not count towards the word count but if you want to include them you will need to upload your answer rather than using the text box.

Under ‘Additional information’ section

Please upload this information separately.

The potential for impact (300 words)

Describe:

  • the potential for the research to have a significant and measurable impact on early intervention in anxiety and/or depression
  • how you have considered the potential uptake of the marker from the outset
  • the potential for the research to have applicability and acceptability in settings beyond the specific setting in which the research is conducted (if appropriate)
  • the high-level ethical implications of the proposed project

Under ‘Other participants’ section

Please provide (300 words):

  • your rationale for a team approach
  • the proposed team composition
  • how your team is positioned to achieve the research (with regard to the complementary skills that they bring and resources that can be accessed)
  • how the collaboration will be managed in the multi-disciplinary teams and the contribution of each team member to the research
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Assessment criteria

For completeness and for applicants’ planning purposes we provide below the full assessment criteria and weightings that will be used at the full application stage. This will only become relevant to shortlisted teams; at the preliminary application stage, a simplified rubric will be used. 

There are four weighted assessment criteria for full applications:   

  1. the potential for impact, the research question, the proposed methodology and the consideration of future development (40%) 

  2. suitability and expertise of the team (20%)  

  3. lived experience involvement (20%)  

  4. suitability of research location, research environment and research culture (20%)  

1. The potential for impact, the research question, the proposed methodology and the consideration of next steps (40%) 

Rationale and potential for impact:  

  • The research has sufficient scope and ambition, such that the findings have the potential to have a significant and measurable impact on early intervention for people with anxiety and/or depression.  

  • The proposed research will further validate proposed biological, psychological, social or digital markers, whether alone or in combination with behavioural or observable characteristics, for use in stratification in anxiety and/or depression.   

  • The proposal is clear on how the selected marker will stratify people with anxiety and/or depression, it is hypothesis-driven, and there is a clear underpinning mechanism. 

  • The proposed research project includes a clearly defined population (strata) and has considered how it meets the needs of end users.  

Strength of evidence: 

  • The proposal includes evidence that supports its feasibility and potential for impact.  

  • The proposal considers similar markers under development in the wider landscape and justifies the rationale for further validation of this marker.  

Strength of methodology: 

  • There is a clear project plan that addresses the research question. 

  • The proposed methodological approach is appropriate, well-designed, feasible, and supported by relevant evidence or expertise (for example, the sample is adequately powered, for human studies a recruitment plan is in place, participant heterogeneity is being harnessed and/or considered in the study design).​  

  • The proposal will move the chosen marker to the next stage of development. 

  • The study incorporates measures of anxiety and depression, which are justified. 

  • The project is achievable in the timelines proposed.​  

  • The resources requested are appropriate and well justified.​ 

Pathway to impact: 

  • Where appropriate, the proposed research has been designed to ensure the findings can be applied beyond the specific setting in which the research was conducted.  

  • Consideration of next steps in development, a potential future implementation strategy, and how the proposed markers could be used in practice. 

  • The team have considered potential risks associated with development and implementation and suggested mitigation strategies.

  • The team have considered the associated ethical implications of the proposed stratification mechanism.

2. Suitability and expertise of the team (20%)  

Lead applicant:  

  • Has research experience relevant to the project, as evidenced through research outputs and/or preliminary data (as appropriate for their career stage). 

  • Has the experience needed to drive and lead a complex collaborative research programme, or the necessary support structures in place to enable this. 

  • Has experience of people and research management and training, as appropriate for their career stage.   

  • Can contribute at least 20% of their research time to this project.  

Co-applicants:  

  • The expertise of the co-applicants is essential for the delivery of the project and their contribution to the project is justified.  

  • The co-applicants have the appropriate time (can contribute at least 20% of their research time) and necessary resources available to deliver the project. 

Team:  

  • The team is diverse and has the necessary expertise and technical skills to deliver the proposed research project. 

  • There is a justified team approach whereby all applicants are necessary to deliver the proposed research and there is evidence that the proposed collaboration would be feasible and fruitful (for example, the team has appropriate management plans in place, describing how the collaboration will be organised and run day-to-day). 

  • The team has the necessary expertise to effectively involve and collaborate with people with lived experience of anxiety and/or depression in the proposed project. 

  • Where research occurs in more than one location, applications include co-applicants based in each country where the research will take place. 

  • Applicants have contributed to and are committed to fostering a positive and inclusive research culture. 

3. Lived experience involvement (20%) 
  • People with lived experience of anxiety and depression are involved in multiple stages of the design, delivery, and dissemination of the project.  

  • Approaches to involvement at each stage of the project should be explained in detail.  

  • The proposed research is feasible from the perspective of lived experience expertise. 

  • People with lived experience are appropriately compensated or paid for their time.   

  • An appropriate number of people with lived experience, with relevant skills are involved in the application. 

  • Plans to involve people with lived experience in the project are appropriately costed and budgeted. 

4. Suitability of research location, research environment and research culture (20%) 

Assessment of this criteria should take into consideration the context, for example, geographical location and local context or commercial environment.  

Research location and environment: 

  • The research environment is suitable to support and develop the applicants and their proposed research.  

  • The research environment(s) is supportive of the research project, has plans to promote a diverse and inclusive environment and will help the applicant to develop their research capabilities, and leadership and management skills. 

  • The applicants have access to the necessary research infrastructure.   

Research culture:  

  • Detailed description of how the applicants will contribute to and develop a positive and inclusive research culture and promote equitable partnerships specifically within multidisciplinary teams, and between diverse team members and low- and middle-income countries' collaborating sites (where applicable).  

Outputs management plans:  

  • Detailed description of a suitable outputs management plan (for example, depositing, sharing and storing data, and open access publishing). 

  • Applicants manage their research outputs in a way that will achieve the greatest health benefit.

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About you

You can apply to this call if you are a team: 

We encourage applications from multi-disciplinary teams, including those outside the life sciences. We consider a broad range of disciplines to be relevant to mental health science, including but not limited to those listed in our mental health funding remit. We want to encourage applications from a range of career stages.

Each application should include the necessary expertise to answer the proposed research question(s) and the contribution of each co-applicant (and collaborator) to the project should be justified. When research occurs in more than one location, applications must include co-applicants based in each country where the research will take place. 

All applications must include the involvement of people with lived experience expertise in the planning, design and delivery of the research.  

Team size should be appropriate for the proposed research.

Lead applicant

You must:  

  • Have the experience, or the necessary support structures in place, needed to drive and lead a research programme to address your proposed research questions in anxiety and/or depression. 

  • Have experience of people and research management and training, as appropriate for your career stage.  

  • Have experience of or demonstrate commitment to effectively leading a team that embeds lived experience as relevant to the project and approach. 

  • Be able to contribute at least 20% of your research time to this project.  

  • Have a permanent, open-ended or long-term rolling contract for the duration of the award, or guarantee of a salaried post, which is not conditional on receiving this award.   

  • Be based at an eligible host organisation that can sign up to our grant conditions.  

  • Only request salary recovery if this is a condition of your employment contract.  

You can only be listed as ‘Lead applicant’ on one application for this call. You can, however, be included as co-applicant on one other application or hold other Wellcome awards but must demonstrate that you have sufficient capacity for both projects if funded. See ‘Who can’t apply’ below for more detail. 

About your co-applicants:

Each co-applicant:  

  • Must be essential for the delivery of the proposed research and make a significant contribution, for example designing the research, writing the application, leading and/or delivering a specific work-package or research aim or managing the programme.

  • Must demonstrate the team’s commitment to effectively embed lived experience as relevant to the project and approach.

  • Must be able to contribute at least 20% of their research time to this project.

  • Does not need to have a permanent, open-ended or long-term rolling contract at their host institution. However, must have a guarantee of space from their host institution for the duration of their commitment to the award.

  • Must be based at an eligible organisation that can sign up to our grant conditions.

  • Can be based in the same or in different organisations, can be at any career stage, and come from any discipline, but the added value of the team approach must be clear. 

You may want to consider involving people with lived experience of anxiety and depression (as appropriate) to be included in the project team, as co-applicants or collaborators. 

Collaborators are distinct from co-applicants in that they will support the delivery of the project (for example, providing technical or knowledge area expertise, access to tools or resources) but are not leading on a specific work package or research aim of the project.

Time spent away from research 

You can apply if you've spent time away from research (for example a career break, parental leave or long-term sick leave). We'll take this into consideration when we review your application. 

If you have retired, please contact us before applying.

Lead and co-applicants can be part-time. There is no formal minimum, but part-time working needs to be compatible with delivering the proposal successfully. 

What’s expected of your host organisation

The organisation can be a: 

  • Higher education institution

  • Research institute

  • Non-academic healthcare organisation

  • Not-for-profit or non-governmental research organisation based anywhere in the world (apart from mainland China). These organisations must be able to sign up to Wellcome’s grant conditions.

  • Company: any commercial organisation based anywhere in the world can apply (apart from mainland China), as long as they can sign up to our grant conditions. You are not eligible for this call if your company is not established and/or doesn't have working capital. Funding to a company may need to occur through a convertible loan, or revenue sharing agreement to ensure public benefit. Please contact us to discuss further. 

If an application involves a collaboration or partnership across multiple organisations, the partners must enter into a suitable collaboration agreement including provisions that covers: 

  • confidentiality 

  • publication rights 

  • access to background intellectual property 

  • ownership of foreground intellectual property

  • arrangements for the protection, management and exploitation of foreground intellectual property

Note that the lead applicant’s host organisation is required under our grant conditions to own all the foreground intellectual property arising from the project and to take the lead in any commercialisation activity. For guidance, applicants are advised to read the university and business collaboration agreements (model heads of terms agreements on GOV.UK). 

We expect organisations based in the UK to meet the responsibilities required by the Concordat to Support the Career Development of Researchers for institutions, companies, managers and researchers.   

Any organisation with Wellcome funding that is based outside the UK is expected, at a minimum, to follow the principles of the Concordat.   

We also expect your host organisation to:   

  • Give you, and any staff employed on the grant, at least ten days a year (pro rata if part-time) to undertake training and continuing professional development (CPD) in line with the Concordat. This can include the responsible conduct of research, research leadership, people management, diversity and inclusion, and the promotion of a healthy research culture. 

  • Provide a system of onboarding, embedding and planning for you when you start the award. 

  • Provide you with the status and benefits of other staff of similar seniority.   

  • If your host organisation is a core-funded research organisation, this award should not replace or lead to a reduction in existing or planned core support.

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Who can't apply

You cannot apply if you intend to carry out activities that involve the transfer of grant funds into mainland China.  

You can only be an applicant on a maximum of two applications to this funding call:  

  • you can be lead applicant on one application (but can be co-applicant on another)

  • you can be a co-applicant on a maximum of two applications to this funding call

  • you must be able to demonstrate that you can dedicate enough time and resources to both projects if funded 

Other Wellcome awards

  • An early-career researcher can be a lead applicant on one Wellcome award and a coapplicant on one other Wellcome award, or a coapplicant on two Wellcome awards.
  • A mid-career researcher can be a lead applicant on one Wellcome award and a coapplicant on two other Wellcome awards, or a coapplicant on three Wellcome awards. 
  • An established researcher can be: 
    • a lead applicant on two Wellcome awards, one as the sole applicant and one as lead applicant for a team, or both as the lead applicant for a team. They can also be a coapplicant on two other Wellcome awards; or
    • a lead applicant on one Wellcome award, as the sole applicant or lead for a team, and a coapplicant on three other Wellcome awards; or
    • a coapplicant on four Wellcome awards.

The awards should be for different research projects, with no overlap in work packages. Information on other open calls from the Mental Health team can be found on the team’s webpage

Please note, if you have previously been unsuccessful for a Wellcome Award at the full application stage, you will need to wait for 12 months before applying again with the same application or the application will require significant modifications.

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We have been running webinars to discuss the call and allow participants to ask the Wellcome Mental Health team questions. A recording of our 6 April webinar in partnership with the World Health Organization is available, where you can watch:

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  • Duration of award: projects of any duration up to 5 years

  • Level of funding: projects of any budget up to £5 million

You should ask for a level and duration of funding that is justifiable for your proposed research. You must justify all costs within the costs section of your application. 

If your proposal is likely to exceed the proposed level or duration of funding, please get in touch with us. 

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Lead applicant

If you are based in the UK or Republic of Ireland, you cannot ask for your salary.

You can ask for a contribution to your salary if you are based in another High Income Country (not UK or ROI) or a LMIC and hold a permanent, open-ended or long-term rolling contract that states that you have to get your salary from external grant funding.

The amount we pay will be proportionate to the time you contribute to the award, for example if you contribute 30% of your time to the award we will fund 30% of your salary.

You will have to contribute at least 20% of your research time to this award.

Your host organisation must confirm:

  • that your employment contract states you must get salary recovery from external grant funding
  • that they will underwrite the salary and post for the period of time that you will be working on the grant.

Coapplicants

You can ask us for a contribution to their salary in your application.

The amount we pay will be proportionate to the time they contribute to the award, for example if they contribute 30% of their time to the award we will fund 30% of their salary.

They will have to contribute at least 20% of their research time to this programme.

Your host organisation must confirm:

  • that the coapplicant’s employment contract states they must get salary recovery from external grant funding
  • that they will underwrite the salary and post for the period of time that the person will be working on the grant.

Staff working on your programme

We will cover the salary costs of all staff, full or part-time, who will work on your grant.

Staff members may include:

  • research assistants or technicians employed on your grant
  • specialist service staff, for example data analysis, fieldwork and clinical studies
  • project manager, if you have multiple applicants on your programme
  • support if you or a member of staff employed on your grant is disabled or has a long-term health condition – see 'Disability-related adjustment support'.

Teaching buyout

If you’re a humanities and social science researcher, you can ask for funds for research or teaching replacement to cover the cost of a temporary replacement lecturer. You must retain at least a 10% commitment to teaching.

Costs:

  • can cover up to 33% FTE of your contracted time
  • are usually for a person at a more junior level than the postholder
  • can be spread across the full period of the grant.

If you already get buyout costs from another grant (funded by Wellcome or elsewhere), you can ask us for this cost, but only for the period of time on your Mental Health Award when you won't receive buyout costs from another grant.

You must provide a letter from your employing organisation, confirming that your contract includes a teaching commitment. You should include this in your grant application.

PhD fees

We do not provide studentships on this award. But if applicants employ a research assistant or a technician on the grant, they can ask for the costs to cover their PhD fees. Each applicant can ask for PhD fees for one research assistant or technician at a time on the grant.

We will only pay the international student fee rate for low- and middle-income nationals who are registered to study for a PhD in a high-income country. In all other situations, we will pay home student fees.

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Staff salaries should be appropriate to skills, responsibilities and expertise. You should ask your host organisation to use their salary scales to calculate these costs, which should include:

  • basic salary
  • employer’s contributions, including any statutory obligations (for example, National Insurance contributions if you’re based in the UK) and pension scheme costs
  • Apprentice Levy charges for UK-based salaries
  • any incremental progression up the salary scale
  • locally recognised allowances such as London allowance.

You should allow for salary pay awards during Year 1. If the pay award is not yet known, applicants should use the International Monetary Fund inflation rate, selecting the ‘inflation, average consumer price’ option as an indicator.

From Year 2 onwards, you should use your organisation’s current pay rates. We’ll provide a separate inflation allowance for salary inflation costs.

Read about the responsibilities of grantholders and host organisations for people working on a Wellcome grant.

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If you have named people on your grant whose salaries will be funded by Wellcome, you can ask for visa or work permit costs to help them take up their posts at the host organisation. You can also ask for:

  • visa costs for the person's partner and dependent children
  • essential associated costs, such as travel to attend appointments at a visa application centre or embassy if you can justify these

Immigration Health Surcharge costs for the person, their partner and dependent children if they will be in the UK for six months or more.

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If you or a member of staff working on your grant is disabled or has a long-term health condition, you can ask for adjustment support to help you carry out your project.

Costs can include, but are not limited to:

  • additional costs for staff to help with day-to-day activities related to your project
  • assistive technology to help use computers, research equipment or materials – for example, text to audio software
  • care costs for assistance animals if you need to travel.

We will not pay for capital or building costs, such as access ramps.

You can ask for these costs if your government and/or employer:

  • does not cover any of the costs
  • only covers some of the costs (if they do, we will only meet the shortfall).

The costs we provide must not replace the support you may get from the government or your organisation, who are responsible for providing these costs.

If you don't know what these costs are now, you can ask for them after we've awarded your grant.

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You can ask for these costs if you are applying from a university, a not-for-profit organisation or a small company.

You can ask for costs to cover the following types of training.

  • Continuing professional development and professional skills training

You can ask for a contribution towards these costs.

Types of training can include:

  • research leadership, professional and people management skills
  • career development support
  • responsible conduct of research
  • diversity and inclusion
  • promotion of a healthy research culture.

We expect your host organisation to provide and fund this training. However, if these types of training are not available, or the quality is inadequate, you can ask for up to £500 a year for you and each member of staff employed on your grant who will be:

  • in post for 12 months or more, and
  • working on the grant for at least 50% of their time.
  • You will need to justify these costs in your application.

Research skills training

You can ask for costs to cover training for the technical and research skills you need to deliver your proposed research.

You can ask for whatever research skills training you need for you, and each member of staff employed on your grant, who will be:

  • in post for 12 months or more, and
  • working on the grant for at least 50% of their time.
  • You will need to justify these costs in your application.
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Continuing professional development and training
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We will pay for the materials and consumables you need to carry out your project, including:

  • laboratory chemicals and materials (for example reagents, isotopes, peptides, enzymes, antibodies, gases, proteins, cell/tissue/bacterial culture, plasticware and glassware)
  • project-specific personal protective equipment (PPE) that is above the standard expected for the setting
  • printing associated with fieldwork and empirical research
  • associated charges for shipping, delivery and freight.
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Materials and consumables
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You can ask for funds to buy animals if they are essential to your project. We will also fund the charge-out rates for animal house facilities if your organisation uses full economic costing methodology. These costs include:

  • running costs (including animal maintenance, any experimental procedures, licences and relevant staff training)
  • appropriate estates costs
  • cage and equipment depreciation costs, but not building depreciation costs.

We may not pay the full charge-out rate for an animal house facility if we've provided significant funding towards the infrastructure and/or core support of the facility.

If your organisation does not use full economic costing methodology to establish charge-out rates for animal house facilities, you can ask for funds to cover:

  • the cost of buying animals
  • running costs (including animal maintenance, any experimental procedures, licences and relevant staff training)
  • staff costs, for example, contributions towards the salaries of animal house technicians.

We will not provide estates or depreciation costs.

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Equipment purchase

You can ask for basic items of equipment that are essential to your research project.

Costs may include purchase, delivery, installation, maintenance and training, where necessary.

We will cover VAT and import duties if:

  • the usual UK exemptions on equipment used for medical research don’t apply
  • you’re applying from a non-UK organisation, and you can show these costs can’t be recovered.

You can also ask for specialised equipment if:

  • it is essential to the success of the proposed research project
  • it is not available at your host organisation or through collaboration, and
  • you’ll be the main user and have priority access to the equipment.

If a complete piece of specialised equipment costs £100,000 or more, we expect a contribution of at least 25 per cent from the host organisation or another source. In some cases, we may expect a larger contribution. We’ll discuss this with you after we’ve assessed your application. Contributions can include benefits in kind, such as refurbishment or the underwriting of a key support post.

Multi-component items must not be broken down into component parts to avoid this contribution.

Equipment maintenance

We will cover maintenance costs for equipment if:

  • you are requesting it in your application
  • it is existing equipment that is:
  • funded by us or another source
  • essential to the proposed research project
  • more than five years old
  • cost effective to keep maintaining it.

We won’t cover maintenance costs for equipment if there is a mechanism in place to recoup these costs through access charges.

Computer equipment

We will cover the cost of one personal computer or laptop per person up to £1,500.

We won't pay for:

  • more expensive items, unless you can justify them
  • installation or training costs.
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You can ask for the cost of access to shared equipment, facilities or services if they’re essential to your project.

These may include materials and consumables, plus a proportion of:

  • maintenance and service contracts
  • staff time costs for dedicated technical staff employed to operate the equipment or facility.

We don’t cover the costs of:

  • estates and utilities
  • depreciation or insurance
  • other staff, for example, contributions towards departmental technical, administrative and management staff time.

If the facilities or equipment were paid for by a Wellcome grant, you can only ask for access charges if:

  • the grant has ended
  • any support for running costs and maintenance contracts has ended.
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You can ask for overheads if your grant will be based at a:

  • university outside the UK or Republic of Ireland
  • research organisation that does not receive core funding for overheads
  • charitable or not-for-profit organisation
  • small or medium-sized commercial organisation.

You can also ask for overheads on any part of your grant that is sub-contracted to any of the organisations listed above.

If you’re based at a UK university you can’t ask for overheads for sub-contracted activity if your university will include the sub-contracted funding in its annual report to the UK Charity Research Support Fund.

Overheads can include:

  • estates, for example building and premises
  • non-project dedicated administrative and support staff
  • administration, for example finance, library, and room hire.

The total cost for overheads should not be more than:

  • 20% of the direct research costs if you’re based in a low- or middle-income country
  • 15% of the direct research costs if you’re based anywhere else.

These costs must directly support the activity funded by the grant.

How to apply for these costs

In your grant application you must:

  • give a full breakdown of costs (you can't ask for a percentage of the research costs)
  • explain why these costs are necessary for your research
  • include a letter from the finance director of your host organisation, or the sub-contracted organisation, confirming that the breakdown is a true representation of the costs incurred.
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You can ask for these costs if you are applying from a university, a not-for-profit organisation or a small company.

Travel costs

Conference attendance

You can ask for a contribution towards the costs of attending scientific and academic meetings and conferences, including registration fees and the costs to offset the carbon emissions of your travel. The limits are:

  • Lead applicant – £2,000 a year
  • Coapplicants on your grant – £2,000 each a year
  • Staff employed on your grant – £1,000 each a year.

We provide costs to cover caring responsibilities for any staff employed on your grant attend a conference. This includes childcare and any other caring responsibility they have. We will pay these if:

  • Wellcome is providing the salary
  • the conference is directly related to the research
  • the caring costs are over and above what they would normally pay for care
  • the conference organiser and their employing organisation are unable to cover the costs.
  • You can ask for up to £1,000 per person for each conference.

Collaborative travel

You can ask for travel and subsistence costs for collaborative visits for you and any staff employed on your grant. You’ll need to justify each visit and its duration.

Other travel

We will pay for other essential visits, for example to facilities, libraries, archives, sample collection and for fieldwork. You can include subsistence costs.

Carbon offset costs

This applies to all types of travel costs Wellcome provides.

You can ask for:

  • the cost of low carbon travel where practical, even if it's more expensive (for example travelling by train instead of flying)
  • project-related resources or activities that provide an alternative to travel, such as video conferencing, communication and file-sharing software
  • costs to offset the carbon emissions of the journeys you make.

We won't pay for the core infrastructure that your host organisation should provide, unless you're eligible to ask for these costs under our overheads policy. Examples of these costs include:

  • organisation-wide video conferencing packages
  • high-speed broadband
  • HD screens.

See our carbon offset policy for travel for information on what you and your organisation need to do.

Subsistence costs

If you’re away for up to one month you can ask for subsistence costs. These include accommodation, meals and incidentals (for example, refreshments or newspapers).

If your administering organisation has a subsistence policy, use their rates.

If your administering organisation doesn’t have a subsistence policy, please use the HMRC rates.

If you’re away for more than one month and up to 12 months, we will pay reasonable rental costs only, including aparthotels. You should discuss appropriate rates with your administering and host organisations, or Wellcome, as appropriate. We expect you to choose the most economical options, booked in advance where possible.

If you’re from a low- or middle- income country and will be working in a high-income country for more than one month and up to 12 months, you can also ask for up to £10 a day to cover extra costs, such as transport and incidentals.

If you’re away for more than 12 months, we will pay the costs of your housing. You should discuss your needs with your administering and host organisations.

The allowance we provide will be based on family and business need. We will set the maximum allowance we pay for each location. This will be based on current market data or, where data is unavailable, in consultation with your administering organisation, using equivalent market rates. Please contact us if you need help calculating the costs.

We will cover the direct expenses you have to pay to find and rent a home. We will not cover the cost of utilities or any refurbishment.

Overseas research

If you or any research staff employed on your grant will be doing research away from your home laboratory, we'll help with the additional costs of working on the project overseas. Please see the 'Overseas allowances' section for details.

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You can ask for these costs if you are

  • applying from a university, a not-for-profit
  • organisation or a small company.
  • you or any staff employed on your
  • grant will be spending time in
  • another country.

If you or any staff employed on your grant will be spending time in another country, we’ll help you with the additional costs of working on the project overseas.

Our overseas allowances are:

  • a contribution towards the personal cost of carrying out research overseas, to ensure that you are not disadvantaged
  • provided on the assumption that you’ll be paying income tax, either in your home country, or the country you will be working in (your personal tax is your responsibility).
  • provided on the understanding that you or your partner will not receive equivalent allowances from elsewhere
  • determined by the amount of time you will spend away from your home country.

Carbon offset costs

We expect the people we fund to choose travel that has a lower carbon impact, where practical, even if it’s more expensive (for example travelling by train instead of flying).

You can ask for costs to offset the carbon generated by the travel, as part of your overseas allowances. If carbon offsetting for travel is not part of your organisational sustainability strategy, you can ask us for a similar level of support for other sustainability initiatives. Your organisation must get our approval for other sustainability initiatives to be included in applications.

See our carbon offset policy for travel for information on what you and your organisation need to do.

See a list of low- and middle-income countries, as defined by the Organisation for Economic Co-operation and Development (OECD).

You can ask for the following allowances. You need to provide estimated costs as accurately as possible.

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If you will be away more than 12 months, we will provide overseas allowances for your partner and any dependants if they are travelling with you.

If you will be away for 12 months or less and can justify why your partner and dependants must travel with you, we may provide overseas allowances for them.

We define your partner as the person:

  • you’re married to
  • you’re not married to but with whom you’ve been in a relationship for at least a year

and

  • you live with at the same permanent address and share some form of joint financial commitment with, such as a mortgage.
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Partners and dependents travelling with you
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We will pay your travel costs at the beginning and end of your overseas work. Costs can be for air, ferry, train or coach fares.

All fares should be:

  • in line with our carbon offset policy
  • booked in advance where possible.
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If you are away for up to 12 months, you can ask for up to 80kg of additional baggage or unaccompanied airline freight for your outward and return journeys.

If you are away for more than 12 months, you can ask for the costs of shipping your personal items at the beginning and end of your overseas work.

We will pay the full cost of transporting:

  • half a standard shipping container if you’re travelling alone
  • a whole standard shipping container (20ft) if you’re travelling with a partner and/or dependants.
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We will pay the cost of your medical insurance and travel insurance.

If you will be working in a low- or middle-income country we will also cover the cost of emergency evacuation cover.

We won’t pay for medical insurance if you will be based in the UK or Republic of Ireland.

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Medical and travel insurance
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We will pay the costs of visas, vaccinations and anti-malaria treatment.

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Visas and vaccinations
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You can ask for this if you’ll be based in a low- or middle-income country and it is necessary.

Costs can include guards, panic buttons and alarms. You should ask your employing organisation for advice on the level of security you need.

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Housing security
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If you’re away for up to one month you can ask for subsistence costs. These include accommodation, meals and incidentals (for example, refreshments or newspapers).

If your administering organisation has a subsistence policy, use their rates.

If your administering organisation doesn’t have a subsistence policy, please use the HMRC rates.

If you’re away for more than one month and up to 12 months, we will pay reasonable rental costs only, including aparthotels. You should discuss appropriate rates with your administering and host organisations, or Wellcome, as appropriate. We expect you to choose the most economical options, booked in advance where possible.

If you’re from a low- or middle- income country and will be working in a high-income country for more than one month and up to 12 months, you can also ask for up to £10 a day to cover extra costs, such as transport and incidentals.

If you’re away for more than 12 months, we will pay the costs of your housing. You should discuss your needs with your administering and host organisations.

The allowance we provide will be based on family and business need. We will set the maximum allowance we pay for each location. This will be based on current market data or, where data is unavailable, in consultation with your administering organisation, using equivalent market rates. If you need help calculating the costs please contact us.

We will cover the direct expenses you have to pay to find and rent a home. We will not cover the cost of utilities or any refurbishment.

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Accommodation and subsistence
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If you’re away for more than 12 months we will pay:

Local nursery or school fees

You can ask for these costs if you are in a location where there isn’t free local education of the same standard as in your home country.

Costs include:

  • local nursery school fees up to a maximum of 30 hours a week for 3 to 4 year olds
  • local junior or secondary school fees, up to the end of secondary school education.

Local international school fees

You can ask for these costs if local schools do not provide the same standard of education as in your home country. We will only pay the published termly school fees.

We will not cover the costs of:

  • extracurricular activities, including field trips
  • other extras including, but not limited to, uniforms, sports kit and equipment, transport, meals, books and electronic equipment.

Boarding school fees

We will consider paying the cost of boarding school fees in your home country if:

  • a local international school is not available
  • both parents, guardians or the sole care giver live outside the home country.

The allowance covers:

  • up to a maximum of £30,000 a year for each child for the published termly fees only
  • the cost of return airfares at the start and end of each school term, in line with our carbon offset policy for travel.

We will not cover the costs of:

  • additional annual leave airfares
  • extracurricular activities, including field trips
  • other extras including, but not limited to, uniforms, sports kit and equipment, transport, meals, books and electronic equipment.

We will cover the cost of providing special needs education as far as possible. Please contact us to discuss your needs.

We would not usually expect to provide an education allowance if you will be working in a high-income country.

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If you will be away for more than 12 months, we’ll pay for you to travel back to your home country for annual leave. This is in addition to your outward and return travel costs and depends on how long you will be away:

12-24 months – 1 annual leave trip

25-36 months – 2 annual leave trips

37-48 months – 3 annual leave trips

49-60 months – 4 annual leave trips

61-72 months – 5 annual leave trips

73-84 months – 6 annual leave trips

85-96 months – 7 annual leave trips.

All fares should be:

  • in line with our carbon offset policy
  • booked in advance where possible.
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If you will be away for more than 12 months, you can ask for up to 100 hours of lessons in the local language for you and/or your partner during the first 12 months of your visit.

We will cover 100% of the costs for local language school classes or up to 50% of the costs of individual tuition.

We will not cover the cost of examinations or personal learning materials such as DVDs and books.

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Language lessons
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Overseas allowances
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We cover fieldwork costs if they’re essential and you can justify them. Costs can include:

  • survey and data collection, including communication and data collection services and any associated costs such as essential field materials, travel costs and language translation services
  • the purchase, hire and running costs of vehicles dedicated to your project
  • expenses for subjects and volunteers, including the recruitment of participants, their participatory fees and travel costs
  • statistical analysis.

You can ask for other fieldwork costs that aren’t listed here, but you’ll need to justify them.

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How we calculate your inflation allowance

We will add an inflation allowance to your award. Your inflation allowance is based on your total eligible costs and the duration of the award.

We will use an inflation allowance that reflects the inflation rate of the country where the host organisation is based using data from the International Monetary Fund (IMF). You'll receive the following allowance if the costs in your application are in pounds sterling.

Award duration (in months)Inflation allowance
0-120.0%
13-241.01%
25-362.04%
37-483.08%
49-604.13%

The costs in your application must be based on current known costs, excluding inflation.

You should allow for salary pay awards during Year 1. These should be based on pay awards already agreed; if you don’t know what the pay award is yet then use the IMF rate for the currency your award will be made in.

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inflation allowance
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If your organisation receives open access block grant funding, you can ask them to cover your open access article processing charges.

If you're at an organisation that does not receive block grant funding, we’ll supplement your grant when your paper has been accepted for publication.

You cannot ask for these charges in your grant application.

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If you need to carry out clinical research using NHS patients or facilities, we will cover some of the research costs.

Annex A of the guidelines for attributing the costs of health and social care research and development (AcoRD) sets out the costs we cover, and which costs should be funded through the Department of Health and Social Care in England, or its equivalent in Northern Ireland, Scotland and Wales. If you're based in the Republic of Ireland, we would expect you to adhere to the spirit of these principles.

Read more information on our clinical trials policy.

If your proposal involves clinical research using NHS resources, check if you need to upload a SoECAT form with your full application.

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Clinical research costs
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You can ask for costs that are essential to the project. These can include:

  • materials, including printing and publishing
  • other costs relating to engagement activities that are essential to carry out your research, such as collaborating with people with lived experience, patient involvement (including under-served groups) and community engagement
  • dissemination of research results and findings arising from Wellcome funded research and workshops.
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If you are involving people at the application design stage, you cannot include a consultation charge for this work. Wellcome will not be held responsible for any costs associated with the production of a response to this funding call.

We expect people with lived experience involved in approved applications to be appropriately compensated or paid for their time. The budget that must be completed during the application process should include appropriate remuneration for lived experience experts and costs for involvement.

We cannot advise on ways to appropriately compensate or pay people with lived experience, as approaches differ between organisations and contexts. However, when thinking about appropriate compensation or payment, we would encourage you to think about the experience, knowledge, and skills that someone will be bringing to the project, as well as their responsibility within the process. Please make sure you are appropriately budgeting for the costs needed to support meaningful involvement, as set out in your proposals. For example, this could include (but not be limited to):

  • consultant fees for lived experience experts on the project
  • travel costs
  • salary costs for lived experience researchers embedded in a team
  • expenses to support meetings or workshops.

It is not possible for us to advise on social security, in terms of people with lived experience being paid for their involvement, as the arrangements will be different in different countries. It is the responsibility of the research team to ensure that they are abiding by any relevant regulations in their context, and we would encourage you to seek advice from relevant local organisations if needed.

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Lived experience involvement
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Public engagement and patient involvement costs
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We will provide funds if you need to outsource project work to:

  • contract research organisations
  • other fee-for-service providers.
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Allowed costs

You may ask for the following costs (you will have to justify them in your application):

  • fieldwork costs, including survey and data collection and statistical analysis
  • specialist publications that are relevant to the research and not available in institutional libraries
  • consultancy fees
  • expenses for subjects and volunteers – includes recruitment of participants, their participatory fees and travel, as well as interviewee expenses
  • reasonable research-associated costs related to the feedback of health-related findings but not any healthcare-associated costs
  • costs associated with developing an outputs management plan
  • questionnaires, recruitment material, newsletters etc for clinical, epidemiological and qualitative research studies
  • public engagement materials where dissemination (including printing and publishing) is a key activity of the project
  • recruitment, advertising and interviewee travel costs for staff to be employed on the grant
  • purchase, hire and running costs of project-dedicated vehicles
  • project-specific personal protective equipment (PPE) that is above the standard expected for the setting
  • costs to host/a contribution towards the cost of hosting:
    • a conference
    • a session within a conference
    • a symposium
    • a seminar series
    • advisory board meetings, if appropriate.
    • The meeting should either be:
    • for research purposes, for example data gathering
    • to disseminate your research findings, for example to policy makers.
    • Costs can include:
      • travel and accommodation for keynote speakers
      • external room hire and catering
      • event publicity and conference materials
      • childcare and other caring responsibility costs for delegates
      • any costs related to accessibility and inclusion.

Disallowed costs

We will not pay for:

  • estates costs – such as building and premises costs, basic services and utilities. This also includes phone, postage, photocopying and stationery, unless you can justify these within a clinical or epidemiological study.*
  • page charges and the cost of colour prints
  • research, technical and administrative staff whose time is shared across several projects and isn’t supported by an audit record*
  • PhD stipends
  • charge-out costs for major facilities* – departmental technical and administrative services, and use of existing equipment
  • cleaning, waste and other disposal costs*
    • *We will fund these costs in the case of animal-related research.
  • indirect costs – this includes general administration costs such as personnel, finance, library, room hire and some departmental services
  • office furniture, such as chairs, desks and filing cabinets
  • clothing such as lab coats and shoes
  • non-research related activities such as catering, room and venue hire for staff parties, team-building events and social activities
  • indemnity insurance (insurance cover against claims made by subjects or patients associated with a research programme)
  • ethics reviews, unless you are in a low- or middle-income country
  • radiation protection costs
  • contingency funds
  • organisation insurance
  • clinical examination or course fees
  • working capital costs of commercial organisations.
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Other costs
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This award includes
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1. Before you apply 

2. Submit your preliminary application  

  • Your application must be submitted by 17:00 (BST) on the deadline day. 

3. Shortlisting 

At the shortlisting stage, Wellcome staff and Wellcome’s lived experience advisors will review your preliminary application. If shortlisted, we will invite you to submit a full application within two months.

All shortlisted applications will receive feedback on the application. No feedback will be offered if your application is not shortlisted due to the quantity of applications that we expect to receive. 

4. Invitation to full application 

  • Complete your full application through our new application portal. More information and guidance will be available after preliminary applications have closed.

  • Submit your application to your host organisation for approval. 

5. Host organisation reviews your application and submits it to Wellcome 

  • Your application must be submitted by 17:00 (BST) on the deadline day in September 2023.  

6. Interviews 

  • A committee will interview shortlisted candidates online and make funding recommendations to Wellcome. Committee membership will be shared with applicants prior to the interview but will be made up of an international panel of experts.  

  • Accessibility requirements will be accommodated.  

  • You will be required to give a presentation to the Committee. Details of the requirements for this presentation will be shared in advance.  

  • The focus of the interview will be on questions and answers. The committee will assess across the full set of criteria rather than one specific aspect of the proposal. They will consider your proposal and interview responses and will make funding recommendations to Wellcome. 

7. Funding decision 

  • Final funding decisions will be made by Wellcome’s Mental Health Team.

  • You will receive an email notification of the funding decision soon after the decision has been made. 

8. Feedback 

  • Written feedback will be provided to those applicants unsuccessful at interview, including the reasons for a decision.
  • Details of how we will handle any personal or confidential information contained in your application are available in our Grants Privacy and Confidentiality Statement.
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You must submit your application by 17:00 (BST) on the deadline day. We don’t accept late applications.

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2 May 2023, 15:00 BST
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Informational webinar
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7 June 2023
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Preliminary application deadline
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July 2023
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Shortlisting
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7 September 2023
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Full application deadline
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November 2023
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Interviews
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Closed to new applications
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contact us
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Useful documents
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Useful documents
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The MRC Framework for Stratified Medicine Research
Content type
Guidance
Meta title
Stratification in Mental Health | Grant funding | Wellcome
Meta description
Wellcome will fund researchers and teams who will validate markers to enable stratification in anxiety and/or depression as early as possible. View a summary of the funding scheme and learn more about the eligibility and suitability requirements, what we offer, how to apply and key deadline dates.
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Funding amount

Up to £5 million

Funding duration

Up to 5 years

Scheme status
Open
Scheme abbreviation
Stratification - Mental Health
Coapplicants
Accepted
Is this scheme currently accepting applications?
Closed to applications
Scheme frequency
Multiple deadline dates
No