Understanding the structure and mechanism of macromolecular machines that regulate chromatin dynamics

<p><span class="ws_rf_style2">Eukaryotic genomes are packed into a highly ordered structure called chromatin, which provides organisation and stability to genetic material. Professor Wigley will study the structure and mechanism of several large protein complexes that interact with nucleosomes to regulate chromatin structure and dynamics in fundamental cellular processes such as transcription, replication and repair.</span></p>