Infectious Disease

Infectious diseases cause around a quarter of all deaths in the world – and the risk of new infections emerging is rising.  

Our modern lifestyles increase this risk. Climate change, global food chains, and international travel enable diseases to spread across the world faster than ever before.   

But what if we could prevent outbreaks from spreading out of control, or even stop new diseases from surfacing in the first place? 

We want to ensure everyone, everywhere is protected from the threat of infectious disease. 

To do this, we support projects that increase our understanding of the sources of infectious disease and the factors that drive disease escalation. In addition, through global cooperation, local leadership, and work with affected communities, we develop accessible and affordable solutions to control the impact of infections.

To have real impact, we need to step-in earlier using more effective interventions. To do this, we want to understand what causes and drives infectious disease to escalate and change the focus to research and development.  

This includes: 

• developing an improved understanding of disease reservoirs – the environment in which an infectious pathogen lives and reproduces 
• developing an improved understanding of how new diseases emerge from environmental zoonotic threats – increased risks of pathogens jumping from animals to humans – drug resistance, and geographical spread 
• developing an improved structure of data and surveillance architecture, so we can better detect and predict escalation 
• fully supporting Research and Development to enable the creation of affordable new products and tools 
• improving the way we undertake clinical trials and ensuring a more equitable regulatory environment. 

Scientific research has already led to the creation of vaccines, treatments, tests, and other measures to help contain numerous infectious diseases that cause illness and death around the world. But many treatments remain inaccessible.   

We will achieve our goals through funding, advocacy, partnerships, and working with communities.   

According to the World Health Organization, infectious diseases are estimated to cause around a quarter of all deaths globally. The risk of new pathogens emerging and escalating – such as SARS2-Cov19 and MERS – is increasing.  

By escalation, we mean the changing factors and systems that allow a pathogen to spread out of control. For example, we know that the drug resistance of malaria, as well as the impact climate change has had on insect vectors – carriers of the pathogen – has allowed malaria to escalate. 

If we can identify what causes and drives infectious disease, we can prevent diseases before they escalate. 

That’s also why we’re funding researchers to develop better medicines and interventions that help control escalating infections or drug-resistant variants once they are identified. We’re investing in three general areas: understanding reservoirs, smart surveillance, alongside targeted affordable interventions. 

The Covid-19 pandemic serves as a stark reminder that the impacts of infectious disease are not felt equally, and that existing structures and systems limit global access to solutions. As such, it is imperative that new medicines and early interventions are affordable and freely available to those that need them. 

We fund research that aims to better understand the reservoirs of disease and the factors that drive disease escalation – such as global connectivity, climate change, and the overuse of antibiotics.

We also focus on how to best map and measure these sources and drivers through improved surveillance. 

We’re interested in funding projects that enable us to transform the field of Research and Development to ensure the creation of accessible, affordable, and available products.  

We also award grants to studies that create the evidence we need to persuade key decision makers, such as local and national governments, to make science-informed choices when devising policy around human disease. 

Additionally, we fund discovery research in a broad range of disciplines, including infectious disease.

We also invite organisations to apply for contract opportunities that support our mission.

Infectious disease funding opportunities 

How is Wellcome funded?

Wellcome is an independent charitable foundation. To find out where we get our grant funding from, visit our investments page.

Wellcome has always supported science to understand and overcome infectious disease. Explore our previous work via the links below.