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New multi-million pound funding available from Wellcome to explore how neuroscience can contribute to our understanding of mental health symptoms.

Standfirst

This award will fund innovative projects that combine computational and experimental neuroscience approaches to improve understanding of symptoms of anxiety, depression and psychosis. Read more about our research priorities, eligibility, how to apply, what your research proposal must include and the research costs that are covered.

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Who can apply
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Who can apply
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Your experience

You can apply to this call if you are a team of researchers: 

We encourage applications from: 

  • diverse and interdisciplinary teams, with collaborations covering multiple areas of expertise (for example, biological, psychological and social)
  • researchers at any stage of their career, including those who are new to the field of mental health science. 

 

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The team must:

  • Include the necessary expertise, technical skills and organisational support to deliver the proposed research.
  • Ensure the contribution of each coapplicant (and collaborator, if applicable) to the project is evident and justified.
  • Consider involving people with lived experience of mental health problems as part of the project team. This can be as lead applicants, coapplicants and/or collaborators, and the team needs to justify their inclusion/exclusion. If included, the overall team should include the skills needed to effectively involve and collaborate with lived experience experts.
  • Demonstrate how they will approach ethical and equitable partnerships, including how this will be approached in partnerships between low- or middle-income country and high-income country researchers. 
  • Include coapplicants based in each country where the research will take place if research is occurring in more than one location. 
  • Be of an appropriate size for the proposed research. Teams must consist of at least two applicants (including the lead applicant) and must not exceed eight applicants (excluding collaborators).
  • Actively foster a diverse, inclusive and supportive research environment within the team and across represented organisations.  
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The lead applicant must:

  • Have the experience needed to drive and lead a collaborative, large-scale research project and/or the necessary support structures in place to enable this. 
  • Have experience of people and research management, as appropriate for their career stage.  
  • Have experience of, or demonstrate commitment to, effectively leading a team that embeds lived experience expertise, as relevant to the research project. 
  • Have a permanent, open-ended or long-term rolling contract (or the guarantee of one) for the duration of the award. The contract should not be conditional on receiving this award.  
  • Be able to contribute at least 20% of their research time to this project.  
  • Be based at an eligible organisation that can sign up to our grant conditions

Read more about who can’t apply.

Read more about when lead applicants can request salary costs, and what other costs can be covered.

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Coapplicants can be based at the same or different organisations as other applicants, including in different countries. They can also be at any career stage and come from any relevant discipline.

Each coapplicant must:

  • Be essential for the delivery of the project and make a significant contribution, for example, in designing the proposed research and leading a specific component of the project. Their involvement should be justified in the application, demonstrating the value of their contribution to the team.
  • Demonstrate the team’s commitment to effectively embed lived experience expertise, as relevant to the research project.  
  • Have a guarantee of space from their administering organisation for the duration of their commitment to the project, but do not need to have a permanent, open-ended or long-term rolling contract.  
  • Be able to contribute at least 20% of their research time to this project.  
  • Be based at an eligible organisation that can sign up to our grant conditions.

Read more about when coapplicants can request salary, and what other costs can be covered.

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Collaborators are distinct from coapplicants as they will support the delivery of the project but will not lead on a specific component of the research. For example, collaborators could provide technical, clinical or subject-matter expertise on statistical analysis or measurement of specific variables. They could also provide access to tools or resources, such as longitudinal datasets, clinical records, or organisations led by or working in collaboration with lived experience experts. Collaborators are not assessed for eligibility and they are not required to give a minimum research time commitment to the award. 
 

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If you’ve spent time away from research

Career breaks, parental leave, sick leave 

You can apply for this award if you have spent time away from research (for example, for a career break, parental leave or long-term sick leave). We will take this into consideration during the review of your application.

Retirement

If you have retired you must contact us before applying. You must have a guarantee of space from your administering organisation for the duration of the award.

Working part-time

Lead and coapplicants can be part-time, but part-time applicants should still be able to contribute at least 20% of their research time to the project. Their part-time work should be compatible with delivering the project successfully.

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Who can't apply
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You can't apply for this call if:

  • You intend to carry out activities that involve the transfer of grant funds into mainland China. 
    • The introduction of the Chinese NGO Law on 1 January 2017 requires foreign NGOs (like Wellcome) to have a representative office in China, or file documentation to carry out temporary activities in order to fund activities in China. Wellcome does not have a representative office in China and a temporary activity licence would not cover the nature of the activities we fund. Consequently we are unable to fund activities in China.
  • You cannot demonstrate that you can dedicate enough time and resources to the project, if funded. 
  • You are already an applicant on two applications to this funding call. 
    • You can only be a lead applicant on one application and a coapplicant on another one 
    • You can be a coapplicant on two applications 
    • You must demonstrate that you have sufficient capacity for both projects if funded. 
  • You already have applied for, or hold, the maximum number of Wellcome awards for your career stage. 

Find out how many Wellcome awards you can apply for, or hold, at one time depending on your career stage.  

Check what kinds of research projects are right for this call.

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Is your organisation right for this call?
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Is your organisation right for this call?
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What your administering organisation must do 

Your administering organisation must:

  • Give the applicant the space and resources they’ll need from the start date to the end date of the award.
  • If based in the UK, meet the responsibilities required by the Concordat to Support the Career Development of Researchers. If based outside the UK, at a minimum the organisation must follow the principles of the Concordat.
  • Give you, and any staff employed on the grant 10 days a year (pro rata if part-time) to undertake training and continuing professional development (CPD) in line with the Concordat to Support the Career Development of Researchers.
  • Provide a system of onboarding, embedding and planning for you when you join the organisation and/or start the award.
  • Provide you with the status and benefits of other academic staff of similar seniority.

Where your administering organisation is based 

Your administering organisation can be based anywhere in the world apart from mainland China.

Your administering organisation can be a:

  • higher education institution
  • research institute
  • non-academic healthcare organisation
  • not-for-profit or non-governmental research organisation.

Commercial organisations are not eligible to apply as administering organisations for this call. However, coapplicants and collaborators can be based at commercial organisations. 

Collaboration agreements 

If your application involves a collaboration or partnership between multiple organisations, the partners must enter into a suitable collaboration agreement, including provisions that cover: 

  • confidentiality 
  • publication rights 
  • access to background intellectual property 
  • ownership of foreground intellectual property 
  • arrangements for the protection, management and exploitation of foreground intellectual property.

The lead applicant’s administering organisation is required under our grant conditions to own all the foreground intellectual property arising from the project and to take the lead in any commercialisation activity. For guidance, applicants are advised to read Wellcome's intellectual property policy

Your research environment 

What is a research environment? 

Wellcome believes that a diversity of people and expertise leads to richer understanding and more impactful discoveries. Excellent research happens in environments where people from all backgrounds are treated with respect, supported and enabled to thrive. 

Our definition of a research environment is not restricted to the quality of the infrastructure, but also considers the culture and behaviours that create excellent research practice. This includes research that is inclusive in design and practice, ethical and engaged with relevant community stakeholders as well as open and transparent. 

Read more about research environment and culture.

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Is your research right for this call?
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Is your research right for this call?
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Research priorities

You must address the following research priority:

  • A focus on understanding the development, maintenance or resolution of one or more symptoms associated with anxiety, depression and/or psychosis. Please state which specific symptom(s) you are planning to investigate.

Researchers must take a symptom-based approach rather than looking solely at diagnostic categories and are required to provide:

  • Evidence that the one or more symptoms you have specified are a core feature of anxiety, depression and/or psychosis (broadly defined; the one or more symptoms chosen may be transdiagnostic or specific to one mental health problem). 
  • A brief explanation of why the one or more symptoms you have specified are important for people with lived experience of anxiety, depression and/or psychosis. This could be evidenced through existing qualitative literature and/or focus groups as part of project development. 

Read more about what we mean by a symptom-based approach.
 

Mental health conditions in scope 

This funding call is focused on projects that investigate symptoms of anxiety, depression and psychotic disorders. This includes:

  • all types of anxiety and depressive disorders (including obsessive compulsive disorder and post-traumatic stress disorder)
  • all forms of psychotic disorders (including schizophrenia, postpartum psychosis and bipolar disorder).

We recognise that the current diagnostic categories are imperfect but removing all categories or creating new ones also presents difficulties. Whilst we do not specify any particular diagnostic or classification system, we expect applicants to use a framework and measurement approach that fits the aim of their study and to provide a clear rationale for doing so.


What your research proposal must include

Your research proposal must feature:

A computational component

We want to fund projects that use computational neuroscience (whether data- or theory-driven computational methods) to understand the mechanisms underpinning symptoms of anxiety, depression and/or psychosis. Read more about what we mean by computational approaches.

An experimental component

Integrated approaches are necessary to understand complex symptoms associated with mental health problems. Projects will need to include an experimental component in at least one experimental model (for example, cellular or animal model) and/or in human participants. Projects relying solely on computational simulation are out of scope. Ideally projects will examine research questions at multiple scales of analysis – at least two from:

  • molecular
  • cellular
  • systems neuroscience
  • cognitive
  • behavioural
  • interpersonal
  • socioenvironmental context. 

A collaborative plan of work that includes mental health practitioners s as well as neuroscientists

Projects will need to bring together neuroscientists and mental health practitioners (whether current or in the past), including but not limited to: 

  • clinical psychologists
  • psychiatrists
  • social workers
  • teachers
  • helpline workers
  • pastoral care supporters
  • counsellors and peer supporters. 

Teams will be required to include such partners, for example:

  • to advise on the clinical relevance of research questions
  • to facilitate participation of patients in research
  • to advise on the development of interventions arising from the research.

Involvement of people with lived experience

Research proposals must involve lived experience expertise unless there is a strong justification for not doing so.

We recognise that there is a range of ways that research teams can involve and collaborate with lived experience experts. This may include, but is not limited to: 

  • expert advisors
  • coapplicants
  • collaborators
  • advisory group members. 

We are open to any methods of involvement that teams choose but it is crucial that lived experience experts are involved in the most appropriate and ethical ways to inform multiple aspects and stages of the research project. 

Consideration of translational impact

Research proposals must consider and clearly describe the potential impact of the proposed project and how, if successful, it would contribute to translational work (either directly or over time) supporting real-world application.  

For example, this could include developing new knowledge that would advance early intervention by identifying potential new opportunities for the prediction, identification and/or intervention in anxiety, depression and/or psychosis. 

One or more of our recommended common measures if conducting research with human participants

Projects with human participants must use, as a minimum, one or more of our recommended common measures in the collection of new data. You may also collect data using any other measure(s). This work must also comply with our policy on research involving human participants.  

Your research proposal is encouraged to include work on diverse or underrepresented populations. 

Kinds of research that are not right for this call 

Research that is not right for this call includes projects that:

  • study symptoms of anxiety, depression and/or psychosis for which there is no/inadequate evidence of clinical importance to people with lived experience of anxiety, depression and/or psychosis
  • focus on the identification of symptoms rather than elucidating their underlying mechanism(s)
  • primarily study symptoms of neurodevelopmental conditions, neurodegenerative diseases, or mental health problems outside of the broad categories of anxiety, depression, and/or psychosis (for example, eating disorders, substance abuse)
  • include only purely experimental or purely computational research
  • focus on evaluating the efficacy or effectiveness of an intervention rather than testing the mechanisms by which the intervention helps to resolve symptoms of anxiety, depression and/or psychosis
  • focus on exploratory or curiosity-driven mechanistic research that is not directly relevant to the scope of the call and the mental health remit.

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You can ask Wellcome to pay for:

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Lead applicant

If you are based in the UK or Republic of Ireland at a higher education institute (HEI), research institute or non-academic healthcare organisation, you cannot ask for your salary.

If you are based at a charity, non-governmental organisation (NGO) or a social enterprise, you can ask for a contribution to your salary, equal to the time you will spend on the award. 

If you are based outside of the UK or Republic of Ireland, you can ask for a contribution to your salary if you hold a permanent, open-ended or long-term rolling contract that states that you have to get your salary from external grant funding.

The amount we pay will be proportionate to the time you contribute to the award, for example if you contribute 30% of your time to the award we will fund 30% of your salary.

You will have to contribute at least 20% of your research time to this award.

Your administering organisation must confirm:

  • that you have to get your salary recovery from external funding to participate in the research
  • that they will underwrite the salary and post for the period of time that you will be working on the grant.

Coapplicants

Coapplicants must contribute at least 20% of their research time to this programme. 

If any coapplicant employed on your grant holds a permanent, open-ended or long-term rolling contract that states that they have to get their salary from external grant funding, you can ask us for a contribution to their salary in your application. 

The amount we pay will be proportionate to the time they contribute to the award, for example if they contribute 30% of their time to the award we will fund 30% of their salary. 

The coapplicant's organisation must confirm: 

  • that the coapplicant has to get their salary from external grant funding to participate in the research 
  • that they will underwrite the post, including any salary costs not covered by Wellcome, for the period of time that the person will be working on the grant. 

Coapplicants can also ask for salary where they: 

  • Are employed by a charity, social enterprise or commercial organisation. The amount they request must be proportionate to the time they will spend on the grant.  
  • Don’t have a permanent, open ended or long-term rolling contract and they: 
    • Will spend 80% of their time on this grant. In this case, they can ask for their full salary. Their post does not need to be underwritten and can be contingent on the application being successful. 
    • Will spend less than 80% of their time on the grant. In this case, they can request salary proportionate to the time they will spend on the grant. The host organisation must guarantee space and salary support if they cannot get it from other sources for the period of time they are working on the grant. Their post cannot be contingent on the application being successful.  
    • Are employed on the award as post graduate research assistants. If they are to spend 100% of their time on the award, their post does not need to be underwritten by the host organisation and can be contingent on the application being successful. 

Alternatively, coapplicants may get their salary through employment on another grant. 

Staff working on your programme

We will cover the salary costs of all staff, full or part-time, who will work on your grant.

Staff members may include:

  • research assistants or technicians employed on your grant
  • experts with lived experience
  • specialist service staff, for example data analysis, fieldwork and clinical studies
  • a project manager, if you have multiple applicants on your programme
  • support if you or a member of staff employed on your grant is disabled or has a long-term health condition.

Read more about disability support for grantholders.

Collaborators

Collaborators cannot ask for a contribution to their salary within the application, but the costs associated with their agreed input into the project, including materials and consumables and project-related travel, can be requested.

Teaching buyout

If you’re a humanities and social science researcher, you can ask for funds for research or teaching replacement to cover the cost of a temporary replacement lecturer. You must retain at least a 10% commitment to teaching.

Costs:

  • can cover up to 33% FTE of your contracted time
  • are usually for a person at a more junior level than the postholder
  • can be spread across the full period of the grant.

If you already get buyout costs from another grant (funded by Wellcome or elsewhere), you can ask us for this cost, but only for the period of time on your Mental Health Award when you won't receive buyout costs from another grant.

You must provide a letter from your employing organisation, confirming that your contract includes a teaching commitment. You should include this in your grant application.

PhD fees

We do not provide studentships on this award. But if applicants employ a research assistant on the grant, they can ask for the costs to cover their PhD fees. Each applicant can ask for fees for up to two research assistants or technicians in total on the grant, to a maximum of eight per team. Early-career applicants (up to and including holders of early-career fellowships) may not supervise a PhD student alone but can be a co-supervisor with a mid-career or established colleague.

We will only pay the international student fee rate for low- and middle-income nationals who are registered to study for a PhD in a high-income country. In all other situations, we will pay home student fees. 

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Staff salaries should be appropriate to skills, responsibilities and expertise. You should ask your host organisation to use their salary scales to calculate these costs, which should include:

  • basic salary
  • employer’s contributions, including any statutory obligations (for example, National Insurance contributions if you’re based in the UK) and pension scheme costs
  • Apprentice Levy charges for UK-based salaries
  • any incremental progression up the salary scale
  • locally recognised allowances such as London allowance.

You should allow for salary pay awards during Year 1. If the pay award is not yet known, applicants should use the International Monetary Fund inflation rate, selecting the ‘inflation, average consumer price’ option as an indicator.

From Year 2 onwards, you should use your organisation’s current pay rates. We’ll provide a separate inflation allowance for salary inflation costs.

Read about the responsibilities of grantholders and host organisations for people working on a Wellcome grant.

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If you have named people on your grant whose salaries will be funded by Wellcome, you can ask for visa or work permit costs to help them take up their posts at the host organisation. You can also ask for:

  • visa costs for the person's partner and dependent children
  • essential associated costs, such as travel to attend appointments at a visa application centre or embassy, and essential English language tests
  • Immigration Health Surcharge costs for the person, their partner and dependent children if they will be in the UK for six months or more.
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If you or a member of staff working on your grant is disabled or has a long-term health condition, you can ask for adjustment support to help you carry out your project.

Costs can include, but are not limited to:

  • additional costs for staff to help with day-to-day activities related to your project
  • assistive technology to help use computers, research equipment or materials – for example, text to audio software
  • care costs for assistance animals if you need to travel.

We will not pay for capital or building costs, such as access ramps.

You can ask for these costs if your government and/or employer:

  • does not cover any of the costs
  • only covers some of the costs (if they do, we will only meet the shortfall).

The costs we provide must not replace the support you may get from the government or your organisation, who are responsible for providing these costs.

If you don't know what these costs are now, you can ask for them after we've awarded your grant.

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We will pay for the materials and consumables you need to carry out your project, including:

  • laboratory chemicals and materials (for example reagents, isotopes, peptides, enzymes, antibodies, gases, proteins, cell/tissue/bacterial culture, plasticware and glassware)
  • project-specific personal protective equipment (PPE) that is above the standard expected for the setting
  • printing associated with fieldwork and empirical research
  • associated charges for shipping, delivery and freight.
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You can ask for the cost of access to shared equipment, facilities or services if they’re essential to your project.

These may include materials and consumables, plus a proportion of:

  • maintenance and service contracts
  • staff time costs for dedicated technical staff employed to operate the equipment or facility.

We don’t cover the costs of:

  • estates and utilities
  • depreciation or insurance
  • other staff, for example, contributions towards departmental technical, administrative and management staff time.

We do cover these costs if related to animal housing facilities.

If the facilities or equipment were paid for by a Wellcome grant, you can only ask for access charges if:

  • the grant has ended
  • any support for running costs and maintenance contracts has ended.
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Equipment purchase

You can ask for basic items of equipment that are essential to your research project. 

Costs may include purchase, delivery, installation, maintenance and training, where necessary.

We will cover VAT and import duties if:

  • the usual UK exemptions on equipment used for medical research don’t apply
  • you’re applying from a non-UK organisation, and you can show these costs can’t be recovered.

You can also ask for specialised equipment if:

  • it is essential to the success of the proposed research project
  • it is not available at your host organisation or through collaboration, and
  • you’ll be the main user and have priority access to the equipment.

If a complete piece of specialised equipment costs £100,000 or more, we expect a contribution of at least 25% of the total costs, including maintenance, from the host organisation or another source. In some cases, we may expect a larger contribution. We’ll discuss this with you after we’ve assessed your application. Contributions can include benefits in kind, such as refurbishment or the underwriting of a key support post. 

Multi-component items must not be broken down into component parts to avoid this contribution.

Equipment maintenance

We will cover maintenance costs for equipment if:

  • you are requesting it in your application
  • it is existing equipment that is:
    • funded by us or another source
    • essential to the proposed research project
    • cost effective and environmentally sustainable to keep maintaining it.

We won’t cover maintenance costs for equipment if there is a mechanism in place to recoup these costs through access charges.

Computer equipment

We will cover the cost of one personal computer or laptop per person up to £1,500.

We won't pay for:

  • more expensive items, unless you can justify them
  • installation or training costs.
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You can ask for funds to buy animals if they are essential to your project. We will also fund the charge-out rates for animal house facilities if your organisation uses full economic costing methodology. These costs include:

  • running costs (including animal maintenance, any experimental procedures, licences and relevant staff training)
  • appropriate estates costs
  • cage and equipment depreciation costs, but not building depreciation costs.

We may not pay the full charge-out rate for an animal house facility if we've provided significant funding towards the infrastructure and/or core support of the facility.

If your organisation does not use full economic costing methodology to establish charge-out rates for animal house facilities, you can ask for funds to cover:

  • the cost of buying animals
  • running costs (including animal maintenance, any experimental procedures, licences and relevant staff training)
  • staff costs, for example, contributions towards the salaries of animal house technicians.

We will not provide estates or depreciation costs.

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We will provide funds if you need to outsource project work to:

  • contract research organisations
  • other fee-for-service providers.
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If you need to carry out clinical research using NHS patients or facilities, we will cover some of the research costs.

Annex A of the guidelines for attributing the costs of health and social care research and development (AcoRD) sets out the costs we cover, and which costs should be funded through the Department of Health and Social Care in England, or its equivalent in Northern Ireland, Scotland and Wales. If you're based in the Republic of Ireland, we would expect you to adhere to the spirit of these principles.

Read more information on our clinical trials policy.

If your proposal involves clinical research using NHS resources, check if you need to upload a SoECAT form with your full application.

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We cover fieldwork costs if they’re essential and you can justify them. Costs can include:

  • survey and data collection, including communication and data collection services and any associated costs such as essential field materials, travel costs and language translation services
  • the purchase, hire and running costs of vehicles dedicated to your project
  • expenses for subjects and volunteers, including the recruitment of participants, their participatory fees and travel costs
  • statistical analysis.

You can ask for other fieldwork costs that aren’t listed here, but you’ll need to justify them.

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Conference attendance

You can ask for a contribution towards the costs of attending scientific and academic meetings and conferences, including registration fees and the costs to offset the carbon emissions of your travel. The limits are:

  • Lead applicant – £2,000 per year
  • Coapplicants – £2,000 each per year
  • Staff employed on the grant – 1,000 each per year

We provide costs to cover caring responsibilities if you or any staff employed on your grant attend a conference. This includes childcare and any other caring responsibility you have. We will pay these if:

  • Wellcome is providing the salary
  • the conference is directly related to the research
  • the caring costs are over and above what they'd normally pay for care
  • the conference organiser and their employing organisation are unable to cover the costs.

You can ask for up to £1,000 per person for each conference.

Collaborative travel

You can ask for travel and subsistence costs for collaborative visits for you and any staff employed on your grant. You’ll need to justify each visit and its duration.

Other travel

We will pay for other essential visits, for example to facilities, libraries, archives, sample collection and for fieldwork. You can include subsistence costs.

Carbon offset costs

This applies to all types of travel costs Wellcome provides.

You can ask for:

  • The cost of low carbon travel where practical, even if it's more expensive (for example travelling by train instead of flying).
  • Project-related resources or activities that provide an alternative to travel, such as video conferencing, communication and file-sharing software.
  • Costs to offset the carbon emissions of the journeys you make. If carbon offsetting for travel is not part of your organisational sustainability strategy, you can ask us for a similar level of support for other sustainability initiatives. Your organisation must get our approval before submitting an application.

We won't pay for the core infrastructure that your host organisation should provide, unless you're eligible to ask for these costs under our overheads policy. Examples of these costs include:

  • organisation-wide video conferencing packages
  • high-speed broadband
  • HD screens.

See our carbon offset policy for travel for information on what you and your organisation need to do.

Subsistence costs

If you’re away for up to one month you can ask for subsistence costs. These include accommodation, meals and incidentals (for example, refreshments or newspapers).

If your administering organisation has a subsistence policy, use their rates.

If your administering organisation doesn’t have a subsistence policy, please use the HMRC rates.

If you’re away for more than one month and up to 12 months, we will pay reasonable rental costs only, including aparthotels. You should discuss appropriate rates with your administering and host organisations, or Wellcome, as appropriate. We expect you to choose the most economical options, booked in advance where possible.

If you’re from a low- or middle- income country and will be working in a high-income country for more than one month and up to 12 months, you can also ask for up to £10 a day to cover extra costs, such as transport and incidentals.

If you’re away for more than 12 months, we will pay the costs of your housing. You should discuss your needs with your administering and host organisations.

The allowance we provide will be based on family and business need. We will set the maximum allowance we pay for each location. This will be based on current market data or, where data is unavailable, in consultation with your administering organisation, using equivalent market rates. Please contact us if you need help calculating the costs.

We will cover the direct expenses you have to pay to find and rent a home. We will not cover the cost of utilities or any refurbishment.

Overseas research

If you or any research staff employed on your grant will be doing research away from your home laboratory, we'll help with the additional costs of working on the project overseas. Please see the 'Overseas allowances' section for details.

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You can ask for these costs if you are applying from a higher education institution, a research institute, a non-academic healthcare organisation, a not-for-profit or non-governmental research organisation or a small company.

If you or any staff employed on your grant will be spending time in another country, we’ll help you with the additional costs of working on the project overseas.

Our overseas allowances are:

  • a contribution towards the personal cost of carrying out research overseas, to ensure that you are not disadvantaged
  • provided on the assumption that you’ll be paying income tax, either in your home country, or the country you will be working in (your personal tax is your responsibility).
  • provided on the understanding that you or your partner will not receive equivalent allowances from elsewhere
  • determined by the amount of time you will spend away from your home country.

Carbon offset costs

We expect the people we fund to choose travel that has a lower carbon impact, where practical, even if it’s more expensive (for example, travelling by train instead of flying).

You can ask for costs to offset the carbon generated by the travel, as part of your overseas allowances. If carbon offsetting for travel is not part of your organisational sustainability strategy, you can ask us for a similar level of support for other sustainability initiatives. Your organisation must get our approval for other sustainability initiatives to be included in applications.

See our carbon offset policy for travel for information on what you and your organisation need to do.

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If you will be away more than 12 months, we will provide overseas allowances for your partner and any dependants if they are travelling with you.

If you will be away for 12 months or less and can justify why your partner and dependants must travel with you, we may provide overseas allowances for them.

We define your partner as the person:

  • you’re married to
  • you’re not married to but with whom you’ve been in a relationship for at least a year

and

  • you live with at the same permanent address and share some form of joint financial commitment with, such as a mortgage.
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We will pay your travel costs at the beginning and end of your overseas work. Costs can be for air, ferry, train or coach fares.

All fares should be:

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If you are away for up to 12 months, you can ask for up to 80kg of additional baggage or unaccompanied airline freight for your outward and return journeys.

If you are away for more than 12 months, you can ask for the costs of shipping your personal items at the beginning and end of your overseas work.

We will pay the full cost of transporting:

  • half a standard shipping container if you’re travelling alone
  • a whole standard shipping container (20ft) if you’re travelling with a partner and/or dependants.
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We will pay the cost of your medical insurance and travel insurance.

If you will be working in a low- or middle-income country we will also cover the cost of emergency evacuation cover.

We won’t pay for medical insurance if you will be based in the UK or Republic of Ireland.

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We will pay the costs of visas, vaccinations and anti-malaria treatment.

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You can ask for this if you’ll be based in a low- or middle-income country and it is necessary.

Costs can include guards, panic buttons and alarms. You should ask your employing organisation for advice on the level of security you need.

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If you’re away for up to one month you can ask for subsistence costs. These include accommodation, meals and incidentals (for example, refreshments or newspapers).

If your administering organisation has a subsistence policy, use their rates.

If your administering organisation doesn’t have a subsistence policy, please use the HMRC rates.

If you’re away for more than one month and up to 12 months, we will pay reasonable rental costs only, including aparthotels. You should discuss appropriate rates with your administering and host organisations, or Wellcome, as appropriate. We expect you to choose the most economical options, booked in advance where possible.

If you’re from a low- or middle- income country and will be working in a high-income country for more than one month and up to 12 months, you can also ask for up to £10 a day to cover extra costs, such as transport and incidentals.

If you’re away for more than 12 months, we will pay the costs of your housing. You should discuss your needs with your administering and host organisations.

The allowance we provide will be based on family and business need. We will set the maximum allowance we pay for each location. This will be based on current market data or, where data is unavailable, in consultation with your administering organisation, using equivalent market rates. If you need help calculating the costs please contact us.

We will cover the direct expenses you have to pay to find and rent a home. We will not cover the cost of utilities or any refurbishment.

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If you’re away for more than 12 months we will pay:

Local nursery or school fees

You can ask for these costs if you are in a location where there isn’t free local education of the same standard as in your home country.

Costs include:

  • local nursery school fees up to a maximum of 570 hours a year for 3 to 4 year olds
  • local junior or secondary school fees, up to the end of secondary school education.
Local international school fees

You can ask for these costs if local schools do not provide the same standard of education as in your home country. We will only pay the published termly school fees.

We will not cover the costs of:

  • extracurricular activities, including field trips
  • other extras including, but not limited to, uniforms, sports kit and equipment, transport, meals, books and electronic equipment.
Boarding school fees

We will consider paying the cost of boarding school fees in your home country if:

  • a local international school is not available
  • both parents, guardians or the sole care giver live outside the home country.

The allowance covers:

  • up to a maximum of £30,000 a year for each child for the published termly fees only
  • the cost of return airfares at the start and end of each school term, in line with our carbon offset policy for travel.

We will not cover the costs of:

  • additional annual leave airfares
  • extracurricular activities, including field trips
  • other extras including, but not limited to, uniforms, sports kit and equipment, transport, meals, books and electronic equipment.

We will cover the cost of providing special needs education as far as possible. Please contact us to discuss your needs.

We would not usually expect to provide an education allowance if you will be working in a high-income country.

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If you will be away for more than 12 months, we’ll pay for you to travel back to your home country for annual leave. This is in addition to your outward and return travel costs and depends on how long you will be away:

  • 12-24 months – 1 annual leave trip
  • 25-36 months – 2 annual leave trips
  • 37-48 months – 3 annual leave trips
  • 49-60 months – 4 annual leave trips
  • 61-72 months – 5 annual leave trips
  • 73-84 months – 6 annual leave trips
  • 85-96 months – 7 annual leave trips.

All fares should be:

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If you will be away for more than 12 months, you can ask for up to 100 hours of lessons in the local language for you and/or your partner during the first 12 months of your visit.

We will cover 100% of the costs for local language school classes or up to 50% of the costs of individual tuition.

We will not cover the cost of examinations or personal learning materials such as DVDs and books.

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You can ask for costs that are essential to the project. These can include:

  • materials, including printing and publishing
  • other costs relating to engagement activities that are essential to carry out your research, such as collaborating with people with lived experience, patient involvement (including under-served groups) and community engagement
  • dissemination of research results and findings arising from Wellcome funded research and workshops.
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If you are involving people with lived experience at the application design stage, you cannot include a consultation charge for this work. Wellcome will not be held responsible for any costs associated with the production of a response to this funding call.

We expect people with lived experience involved in approved applications to be appropriately compensated or paid for their time. The budget that must be requested during the application process should include appropriate remuneration for lived experience experts and costs for involvement.

We cannot advise on ways to appropriately compensate or pay people with lived experience, as approaches differ between organisations and contexts. However, when thinking about appropriate compensation or payment, we would encourage you to think about the experience, knowledge and skills that someone will be bringing to the project, as well as their responsibility within the process. Make sure that you have appropriately budgeted for the costs needed to support meaningful involvement, as set out in your proposal. For example, this could include (but not be limited to):

  • consultant fees for lived experience experts on the project
  • travel costs
  • salary costs for lived experience researchers embedded in a team
  • expenses to support meetings or workshops.

It is not possible for us to advise on social security, in terms of people with lived experience being paid for their involvement, as the arrangements will be different in different countries. It is the responsibility of the research team to ensure that they are abiding by any relevant regulations in their context, and we would encourage you to seek advice from relevant local organisations if needed.

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You can ask for overheads if your grant will be based at a:

  • university outside the UK or Republic of Ireland
  • research organisation that does not receive core funding for overheads
  • charitable or not-for-profit organisation.

You can also ask for overheads on any part of your grant that is sub-contracted to any of the organisations listed above, including if you're sub-contracting to small or medium commercial organisations.

If you’re based at a UK university, you can’t ask for overheads for sub-contracted activity if your university will include the sub-contracted funding in its annual report to the UK Charity Research Support Fund.

Overheads can include:

  • estates, for example building and premises
  • non-project dedicated administrative and support staff
  • administration, for example finance, library and room hire.

The total cost for overheads should not be more than:

  • 20% of the direct research costs if you’re based in a low- or middle-income country
  • 15% of the direct research costs if you’re based anywhere else.

These costs must directly support the activity funded by the grant.

How to apply for these costs

In your grant application you must:

  • give a full breakdown of costs (you can't ask for a percentage of the research costs)
  • explain why these costs are necessary for your research
  • include a letter from the finance director of your host organisation, or the sub-contracted organisation, confirming that the breakdown is a true representation of the costs incurred.
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You can ask for these costs if you are applying from a higher education institution, a research institute, a non-academic healthcare organisation, a not-for-profit or non-governmental research organisation or a small company. 

Continuing professional development and professional skills training

You can ask for a contribution towards these costs. 

Types of training can include: 

  • research leadership, professional and people management skills 
  • career development support 
  • responsible conduct of research 
  • diversity and inclusion 
  • promotion of a healthy research culture.

We expect your host organisation to provide and fund this training. However, if these types of training are not available, or the quality is inadequate, you can ask for up to £500 a year for you and each member of staff employed on your grant who will be: 

  • in a post of 12 months duration or more only and 
  • working on Wellcome funded awards for at least 50% full time equivalent.

You will need to justify these costs in your application. 

Research skills training 

You can ask for costs to cover training for the technical and research skills you need to deliver your proposed research. 

You can ask for whatever research skills training you need for you, and each member of staff employed on your grant, who will be: 

  • in a post of 12 months duration or more only and 
  • working on Wellcome funded awards for at least 50% full time equivalent. 

You will need to justify these costs in your application.

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If your organisation receives open access block grant funding, you can ask them to cover your open access article processing charges.

If you're at an organisation that does not receive block grant funding, we’ll supplement your grant when your paper has been accepted for publication.

You cannot ask for these charges in your grant application.

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How we calculate your inflation allowance

We will add an inflation allowance to your award. Your inflation allowance is based on your total eligible costs and the duration of the award.

We will use an inflation allowance that reflects the inflation rate of the country where the host organisation is based using data from the International Monetary Fund (IMF). You'll receive the following allowance if the costs in your application are in pounds sterling.

Award duration (in months)Inflation allowance
0-120.0%
13-241.01%
25-362.04%
37-483.09%
49-604.13%
61-725.20%
73-846.28%
85-967.38%

The costs in your application must be based on current known costs, excluding inflation.

You should allow for salary pay awards during Year 1. These should be based on pay awards already agreed; if you don’t know what the pay award is yet then use the IMF rate for the currency your award will be made in.

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Allowed costs

You may ask for the following costs (you will have to justify them in your application):

  • specialist publications that are relevant to the research and not available in institutional libraries
  • consultancy fees, including for lived experience experts
  • expenses for subjects and volunteers – includes recruitment of participants, their participatory fees and travel, as well as interviewee expenses
  • reasonable research-associated costs related to the feedback of health-related findings but not any healthcare-associated costs
  • costs associated with developing an outputs management plan
  • questionnaires, recruitment material, newsletters etc for clinical, epidemiological and qualitative research studies
  • public engagement materials where dissemination (including printing and publishing) is a key activity of the project
  • recruitment, advertising and interviewee travel costs for staff to be employed on the grant
  • purchase, hire and running costs of project-dedicated vehicles
  • project-specific personal protective equipment (PPE) that is above the standard expected for the setting 
  • costs to host/a contribution towards hosting: 

    • a conference 
    • a session within a conference 
    • a symposium 
    • a seminar series 
    • advisory board meetings, if appropriate. 

    The meeting should either be: 

    • for research purposes, for example data gathering 
    • to disseminate your research findings, for example to policy makers. 

    Costs can include: 

    • travel and accommodation for keynote speakers 
    • external room hire and catering 
    • event publicity and conference materials 
    • childcare and other caring responsibility costs for delegates 
    • any costs related to accessibility and inclusion.

Disallowed costs

We will not pay for:

  • estates costs – such as building and premises costs, basic services and utilities*
  • phone, postage, photocopying and stationery, unless you can justify these within a clinical or epidemiological study
  • page charges and the cost of colour prints
  • research, technical and administrative staff whose time is shared across several projects and isn’t supported by an audit record*
  • PhD stipends
  • cleaning, waste and other disposal costs*
  • indirect costs – this includes general administration costs such as personnel, finance, library, room hire and some departmental services
  • office furniture, such as chairs, desks and filing cabinets
  • clothing, such as lab coats and shoes
  • non-research related activities such as catering, room and venue hire for staff parties, team-building events and social activities
  • indemnity insurance (insurance cover against claims made by subjects or patients associated with a research programme)
  • ethics reviews, unless you are in a low- or middle-income country
  • radiation protection costs
  • contingency funds
  • organisation insurance
  • clinical examination or course fees
  • working capital costs of commercial organisations.

*We will fund these costs in the case of animal-related research.

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Before you apply

  • Make sure you read everything on this page.
  • You do not need to contact us before your write and submit your application.

Submit your application to your administering organisation for approval

  • Complete your application form on Wellcome Funding platform.
  • Submit it to the 'authorised approver' at your administering organisation for approval. Make sure you leave enough time for the approver to review and submit your application before the deadline. The approver may ask you to make changes to your application.

Administering organisation approves and submits it to Wellcome

  • Your application must be submitted by 17:00 (BST) on the deadline day. 

Shortlisting

  • We will check your eligibility for the call and that your application is within the call’s remit. If your application is ineligible or is not within the remit of the funding call, we will withdraw your application and contact you to explain why.
  • A committee will assess eligible and in remit applications against the assessment criteria outlined below, to make shortlisting recommendations to Wellcome.
  • Committee membership will be comprised of a diverse range of international members and will take into account Wellcome’s diversity and inclusion priorities.
  • If your application is shortlisted, we will invite you for interview. 

Written expert review 

  • We will seek external written expert review on shortlisted applications. Reviewers will be selected based on their expertise within the relevant research field and not on their level of seniority.
  • Unattributed comments will be sent to shortlisted applicants before the interview.

Interview

  • The committee will interview shortlisted applicants online and make funding recommendations to Wellcome. 
  • The lead applicant will attend the interview, accompanied by up to two coapplicants. 
  • Accessibility requirements will be accommodated. 
  • You will be asked to give a presentation at the start of your interview. Details of the requirements for this presentation, and the date when slides need to be submitted to Wellcome, will be shared in advance. 
  • We will provide further information on the structure of the interview, room layout and committee membership before the interview. 
  • The focus of the interview will be on questions and answers. The committee will assess the application against the full set of assessment criteria, rather than one specific aspect of the proposal. 
  • The committee will consider your application, the expert reviewers’ comments and interview responses when making funding recommendations to Wellcome.

Funding decision

  • Final funding decisions will be made by Wellcome’s Mental Health Team.
  • You will receive an email notification of the funding decision soon after the decision has been made in December 2024.
  • The reasons for a decision will be provided to unsuccessful applicants in writing.
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Timing considerations for your application

You must leave enough time to make sure:

  • you read everything on this page before applying
  • you and your coapplicant(s) have time to complete the application
  • your administering organisation has time to review, offer feedback and for you to apply any amendments suggested
  • the authorised organisational approver at your administering organisation has time to approve and submit your application to Wellcome by 17:00 BST on 23 July 2024.

Getting support with your application

We offer disability-related support for applicants. Read the disability-related support guidance if you:

  • are disabled or have a long-term health condition and you need help applying for funding
  • need help completing your project, for example, asking for costs for assistive technology.

If you need further support with completing your application or need to request an extension to the deadline, please contact us.

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Mental Health Award webinar 

Watch the recording of our funding webinar below to hear directly from Wellcome’s mental health team as they explain the rationale, objectives and eligibility for this funding call. 

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Jump to a specific section:

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For consistency, we will evaluate all applications using the same weighted assessment criteria.

Essential criteria and weightings

Research question(s) and proposed methodology (40% weighting)

Potential and impact 

  • The proposed research must lead to an increased understanding of the mechanisms underpinning the development, maintenance and/or resolution of one or more symptoms associated with anxiety, depression and/or psychosis.
  • The project will contribute (directly or in time) towards translational research. This could include, for example, developing new knowledge that would advance early intervention by identifying potential new opportunities for the prediction, identification and/or intervention in anxiety, depression and/or psychosis. We have produced a report to help researchers in mental health consider the translational impact of their research from the earliest stages.

Rationale and strength of evidence​ 

  • There is evidence that the chosen symptoms are a core feature of anxiety, depression and/or psychosis.
  • The rationale for choosing a particular symptom includes:
    • Evidence that the symptom is considered relevant and important to people with lived experience who are most applicable to your research (a brief rationale is sufficient).
    • An explanation as to how understanding more about the symptom will have implications for advances in translational research.

Proposed methodology

  • The research design clearly addresses the research question(s) and proposed hypothesis, seeking to gain insights into how symptoms develop, persist and/or resolve.
  • The research design features:
    • Computational research methods. 
      Model-based methods should describe and/or explain the mechanisms underpinning symptoms of anxiety, depression and/or psychosis. Model-free methods should be used as a tool in the service of improving understanding of mechanisms underpinning symptoms of anxiety, depression and/or psychosis.
    • An experimental component in at least one experimental model and/or in human participants.
  • The project is well-designed and feasible using the resources and timelines proposed (for example, a recruitment plan is in place and is achievable, and all components of the project have been appropriately costed). 
  • If the project includes work on diverse or underrepresented populations, the study design includes a plan to mitigate biases that might disproportionately impact these populations (for example, through sampling approaches, study site selection, inclusion/exclusion criteria or sub-group analyses).
     

Suitability and expertise of the team (20% weighting)

The project must feature an integrated, collaborative plan of work that includes mental health practitioners and individuals with lived experience as well as basic scientists.

The lead applicant has (appropriate to their career stage): 

  • research experience relevant to the project, as shown through research outputs and/or preliminary data
  • the experience needed to drive and lead a collaborative, large-scale research project and/or the necessary support structures in place to enable this
  • experience of people and research management.

The coapplicant(s)​ has/have: 

  • the expertise needed to deliver the project, with their contribution to the project being significant and justified
  • the appropriate time and necessary resources available to deliver the project.  

The team​: 

  • has the necessary expertise and technical skills, as well as the appropriate variety of disciplines and perspectives, to deliver the proposed project
  • includes lived experience experts and/or has the necessary skills to effectively involve and collaborate with people with lived experience of mental health problems in the proposed research
  • has members who are all necessary to deliver the proposed research and there is proof of concept that the proposed collaboration will be feasible and effective (for example, the team has appropriate management plans in place describing how the collaboration will be equitably organised and managed day-to-day)  
  • has contributed towards and is committed to fostering a positive and inclusive research environment, which demonstrates a commitment to equity, diversity and inclusion.  

Lived experience involvement (20% weighting)

  • People with lived experience are meaningfully involved  at multiple stages, including the conception, planning, design, delivery and dissemination of the project. There is a clear rationale for their inclusion (or exclusion) at each stage. You can access guidance on embedding lived experience expertise in your research.
  • Lived experience perspectives are represented across the project, including in leadership and governance roles. 
  • Lived experience experts have relevant experience and expertise applicable to the research, including being representative of the research  location. 
  • People with lived experience are compensated appropriately for their time.  


Suitability of research location and approach to research environment (20% weighting)

Research location  

  • The administering organisation is supportive of the research project. For example, it aligns with the organisation’s strategy and it provides in-kind or financial support in the form of PhD students, administrative or technical support, and training opportunities. 
  • The applicants have access to the necessary research infrastructure. For example, access to a magnetic resonance imaging scanner for projects involving human neuroimaging.

Research environment

  • Provide a detailed description of how the team will foster a positive and inclusive research culture. This could include, but is not limited to, information about:
    • career development
    • research practices
    • leadership
    • team composition and partnership
    • appropriate safeguarding measures for team members and collaborators, including people with lived experience.
  • Provide information and a plan on how to manage an integrated collaborative project.

Ethical, open, equitable and engaged research conduct​ 

  • Include an implementation plan with details about appropriate oversight, governance, monitoring, standard operating procedures and methods for course correction (as needed).
  • Write a detailed description of a suitable outputs management plan.
  • Provide information about how the research outputs will be made available to those who need them (for example, policymakers, communities and industry) and in which formats. 
  • Provide details about the relevant ethical, social and cultural implications of the proposed work, and how the study team plans to manage these issues, both in the conduct and oversight of the study and in the communication of its findings. 
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April 2024
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Two events: 25 April 16.00 UTC; 30 April 04.00 UTC
Register here for Neuromatch

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14 May 2024
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9 July 2024
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23 July 2024
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September 2024
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3 - 5 December 2024
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December 2024
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Our mental health strategy

Wellcome’s mental health strategic aim is to drive a transformative change in our ability to intervene as early as possible in the course of anxiety, depression and psychosis. Importantly, we must do this in ways that reflect the priorities and needs of people who experience these problems. 

This Mental Health Award will fund collaborative research projects that include the use of computational methods to improve understanding of symptoms of anxiety, depression and/or psychosis. Novel insights should be directly applicable to developing new or improved interventions.

Our rationale for this call

We conducted a series of scoping activities to explore how cellular, animal and computational neuroscience could best contribute to advancing Wellcome’s Mental Health strategy. The resulting report – Harnessing the potential of cellular, animal and computational neuroscience models for mental health – highlighted the need for research that applies these methods in combination to specific mental health symptoms to gain insights that would be impossible with each approach alone. 

The scoping also emphasised the importance of collaboration between neuroscientists, mental health practitioners and people with lived experience. Together, their insights and experience can take us from theory into practice. 

Only by bringing together these specialisms can we truly reflect and respond to the complexity of these mental health problems and contribute to their improved early diagnosis, treatment and cure – an outcome that would improve the lives of millions of people worldwide. 

This Mental Health Award will therefore fund research projects that will help us achieve our mission by combining the following key themes and approaches:

  • A symptom-based approach that aligns laboratory research with the needs of patients. Research priorities should be informed by the experience of people living with these symptoms and how they affect their daily functioning. Clinical research should shape the questions asked in cellular and preclinical animal models. This approach both relates to human experience and provides plausible constructs to model in the lab.
  • Use of computational methods that can bridge the gap between model and human studies. They involve using mathematical tools and theories to study brain function and simulate underlying mechanisms observed in data. There are two main approaches: 

    • Theory-driven approach: considered a 'top-down' approach, involves explicit theory-based hypothesis testing using controlled experimental paradigms.
    • Data-driven approach: a 'bottom-up' approach, uses machine learning to identify patterns and features indicative of psychiatrically relevant variables.  

    We are looking to fund projects that use either approach to understand the neural, cognitive or behavioural processes underlying anxiety, depression and/or psychosis. It is important for computational models to accurately mimic the complex changes seen in these mental health problems.

    For more info on computational models refer to section 1.3.2 of the Harnessing the potential of cellular, animal and computational neuroscience models for mental health report.   

    This worked example, and resource for researchers and data scientists, demonstrates how to measure, mitigate and communicate algorithmic bias in a predictive model for mental health

  • We want collaborative projects that bring together experimental and theoretical neuroscientists with mental health practitioners as well as individuals with lived experience of mental health problems. Read more about what we mean by ‘people with lived experience’, including guidance for meaningful involvement. The goal is to bridge the gap between our understanding of anxiety, depression and/or psychosis, and early intervention. Wellcome has partnered with Neuromatch to help applicants find potential collaborators through an online networking event. Read more about how to join these online events. 
  • Research projects should consider translation from the outset to have the potential to contribute to interventions, treatments and cures. We encourage applicants to design their research with future advancement in mind, even if they are at an early stage in the pipeline. You can access guidance on this in our recent report supporting mental health researchers in planning a translation pathway for their research. By improving our understanding of how symptoms emerge, develop and resolve, the ultimate aim of this call is to find better ways to identify these problems early-on and to intervene at the most critical and earliest possible timepoints. 
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New multi-million pound funding available from Wellcome to explore how neuroscience can contribute to our understanding of mental health symptoms.
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Funding amount

£2-5 million per project team

Funding duration

3 to 5 years

Scheme status
Open
Scheme abbreviation
Neuroscience
Coapplicants
Accepted
Scheme closes for applications
Is this scheme currently accepting applications?
Open to applications
Scheme frequency
Multiple deadline dates
No